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The underlying mechanism involves multiple genetic mutations that results in rapid cell division. Symptoms may include feeling tired, pale skin color, fever, easy bleeding or bruising, enlarged lymph nodes, or bone pain. During treatment you may experience a decrease in libido and it may take some time for things to return to ‘normal’. Some women experience decreased sexual drive, anxiety and even depressive symptoms during this time. Most people experience some degree of tiredness in the days and weeks following chemotherapy and radiotherapy.
Hair loss is unfortunately a very common side effect of chemotherapy and some forms of radiotherapy. It is important to keep your mouth as clean as possible while you are having treatment to help prevent infection. It usually starts about a week after the treatment has finished and goes away once your blood count recovers, usually a couple of weeks later. Mucositis, or inflammation of the lining of the mouth, throat or gut is a common and uncomfortable side effect of chemotherapy and some forms of radiotherapy. Some people find that eating smaller meals more frequently during the day, rather than a few large meals, helps to reduce nausea and vomiting. You will be given anti-sickness drugs before and for a few days after your chemotherapy treatment.
Environmental risk factors are also needed to help create enough genetic mutations to cause disease. These genes, in turn, increase the risk that more mutations will occur in developing lymphoid cells. ALL emerges when a single lymphoblast gains many mutations to genes that affect blood cell development and proliferation.
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Tyrosine-kinase inhibitors (TKIs), such as imatinib, are often incorporated into the treatment plan for people with Bcr-Abl1+ (Ph+) ALL. Chemotherapy is the initial treatment of choice, and most people with ALL receive a combination of medications. Over the past several decades, there have been strides to increase the efficacy of treatment regimens, resulting in increased survival rates. While many symptoms of ALL can be found in common illnesses, persistent or unexplained symptoms raise suspicion of cancer. These lymphoblasts build up in the bone marrow and may spread to other sites in the body, such as lymph nodes, the mediastinum, the spleen, the testicles, and the brain, leading to the common symptoms of the disease.
Hormone changes can lead to many of the classic symptoms of menopause. Some cancer treatments can affect the normal functioning of the ovaries. There are some options for preserving your fertility, if necessary, while you are having treatment for leukaemia. If possible, before you commence treatment you should discuss any questions or concerns you might have regarding your future fertility with your doctor. The hair can start to fall out within a couple of weeks of treatment and tends to grow back three to six months later.
Stem cell transplantation may be used if the disease recurs following standard treatment. Treatment can also include radiation therapy if ALL has spread to the brain. Acute lymphoblastic leukemia is typically treated initially with chemotherapy aimed at bringing about remission. Some hypothesize that an abnormal immune response to a common infection may be a trigger. Environmental risk factors may include significant radiation exposure or prior chemotherapy. Genetic risk factors may include Down syndrome, Li–Fraumeni syndrome, or neurofibromatosis type 1. As an acute leukemia, ALL progresses rapidly and is typically fatal within weeks or months if left untreated.
The main symptoms of ALL are caused by a lack of normal circulating blood cells. Research is going on all the time into possible causes of this damage, and certain factors have been identified that may put some people at an increased risk. The characteristics of ALL differ greatly between children and adults. ALL is the most common type of childhood leukaemia, and the most common childhood cancer. More than 300 adults and children are diagnosed with ALL each year in Australia. T-cell ALL commonly presents with a high white blood cell count and involvement of the central nervous system at diagnosis.